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マウスにおいてCFTR 阻害剤含有食の投与は便秘を誘導する
https://doi.org/10.57426/0002000083
https://doi.org/10.57426/00020000835be3562e-b126-4572-8d65-e94c78740c13
| 名前 / ファイル | ライセンス | アクション |
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HLSv14-p1-9.pdf (988 KB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||||||||
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| 公開日 | 2024-05-09 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | マウスにおいてCFTR 阻害剤含有食の投与は便秘を誘導する | |||||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Administration of a Diet Containing CFTR Inhibitor Causes Constipation in Mice | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | jpn | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | CFTR | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | constipation | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | mouse | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | CFTR inhibitor | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||||||||
| ID登録 | ||||||||||||||||||||||||
| ID登録 | 10.57426/0002000083 | |||||||||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||||||||
| 著者 |
浦本, 裕美
× 浦本, 裕美
× 辻, 美由貴
× 川崎, 美波
× 高橋, 彩花
× 竹内, 里奈
× 前田, 祥佳
× 松村, 和美
× 村本, 花奈
× 山岸, 七菜
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| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | Cystic fibrosis (CF) is a recessive genetic disorder caused by a functional deficiency in cystic fibrosis transmembrane conductance regulator (CFTR) function. CF has long been associated with lung disease but can also severely affect gastrointestinal tissues. CF carriers̶those with a CF-predisposing genetic mutation̶have several CF-related symptoms, including constipation. In addition, some of the newer drugs for chronic constipation have a mechanism of action that stimulates CFTR function, suggesting that CFTR function is closely related to the development of constipation. However, there have been no recent studies on whether CFTR dysfunction causes constipation. In this study, to examine whether inhibiting CFTR function in the intestine induces constipation, we fed mice food containing CFTRinh172, a CFTR-specific inhibitor. The results showed that the fecal water content (22.49%) was 74% of that of the control group (30.45%; p = 0.15 vs. the control group) on day 13 after inhibitor administration. After switching to the normal diet, the average fecal water content recovered to almost the same level as that of the control group on day 3. There was a significant decrease in fecal water content on day 13 of the inhibitor treatment compared to day 5 after diet switching, when fecal water content recovery was stable (30.50%; p < 0.05). Furthermore, the fecal transit time was prolonged from 26 to 30 hours in the inhibitortreated mice compared to 24 hours in the control mice. In conclusion, constipation was induced in mice that received approximately 20 μg of CFTRinh172 daily for 13 days. The effects of the CFTR inhibitor on constipation disappeared relatively quickly after discontinuing inhibitor administration, suggesting that the constipation symptoms were caused by the inhibition of CFTR function in the intestine. | |||||||||||||||||||||||
| 書誌情報 |
仁愛大学研究紀要. 人間生活学部篇 Research journal of Jin-ai University, faculty of human life studies 号 15, p. 1-9, 発行日 2024-02-20 |
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| 出版者 | 仁愛大学 | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 21853363 | |||||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
